`SO(10) meets LHC' Abstract: In terms of physics results, 2012 has been an exciting year. In July 2012, the ATLAS and CMS collaborations have discovered a new particle that is consistent with the Standard Model Higgs boson. At the same time, the LHC has pushed the lower limits for supersymmetric particles to new heights, and this has contributed to the anxiety in the physics community that SUSY, if realized in nature, may not be "natural" after all. Complementary to these "direct" searches for new physics, the LHCb experiment has presented in November 2012 the first evidence for the rare decay B_s -> mu+ mu- which strongly constrains supersymmetric models with large tanbeta. However, the new results have not been limited to collider searches. In early 2012, the Daya Bay and Reno collaborations have measured a "large" neutrino mixing angle theta13 of about 9 degrees, thereby strongly disfavoring the tribimaximal mixing scenario which has been a paradigm in neutrino physics for the last decade. Also, the Xenon100 experiment has started to probe regions of the SUSY parameter space which are "preferred" by many models. In my talk, I will explore the consequences of these experimental results on generic SO(10) models with Yukawa unification in general, and on the so-called Dermisek-Raby (DR) model in particular. After motivating why we might expect a grand unified gauge group at some larger energy scale, I will introduce the DR-model and discuss how well it fits current data in light of the recent experimental results. I will conclude with predictions of the DR model that are testable at the LHC.