------------------------------------------------------------------------- `Yukawa unification in SO(10) confronts the LHC' Abstract: In SO(10) SUSY GUT the top, bottom and tau Yukawa couplings unify at the GUT scale. Yukawa unification (YU) prefers the negative sign of the Higgs-mixing parameter mu. However, negative mu is typically disfavoured by the measurements of the muon anomalous magnetic moment (g-2). This is the reason why most of the studies so far have been devoted to the case of positive mu. Those studies show that YU is very hard to obtain in a natural way when mu is positive. We study an SO(10) model in which mu is negative and YU may be realized in a way consistent with all the phenomenological constraints due to an appropriate pattern of non-universal soft masses for scalars and gauginos. Special emphasis is given to the interplay between constraints coming from BR(b->s gamma), the muon anomalous magnetic moment and the relic density of the lightest neutralino. In the region of parameter space where these constraints are simultaneously satisfied the SUSY spectrum turns out to be light enough to be detected at the LHC. It is also shown that the recent LHC searches for SUSY already set some constraints on the model but large portion of the parameter space are still consistent with all experimental data. -------------------------------------------------------------------------