A better understanding of string theory can be gained by exploring its behaviour at high energies. It is in this limit that, as the inelastic scattering channels grow in importance and variety, the extended nature of the string becomes manifest. In the same limit, the strength of the gravitational interactions is also enhanced and we can address some of the fundamental problems posed by a theory of quantum gravity. I will study a simple system, a highly-energetic closed string colliding with a stack of parallel D-branes. Analyzing this process, we will be able to explore several aspects of string and gravitational interactions: the emergence of classical gravitational effects from the string S-matrix in flat spacetime; the dynamical excitation of the massive, higher-spin states of the string spectrum; the existence of a unitary description for the infall of a string in a spacetime singularity. I will also discuss how causality and the behaviour of the scattering amplitudes in the Regge limit constraint the higher derivative corrections to general relativity.